There is increasing evidence that gynecological disorders associated to chronic pelvic pain (CPP) and co-morbid diseases are characterized by a neuroimmune dysregulation, involving mainly mast cells' (MC) distribution/function and nerve terminal fibers. MCs dysregulation might also promote spinal and supraspinal alterations associated with CPP...

Chronic inflammation, pain and depression are a clinical triad increasingly recognized as co-morbid. Peripheral and central inflammation can alter neuronal activity, thereby contributing to the psycho-emotional and somatic symptoms of depression...

Uncomplicated recurrent urinary tract infections (rUTIs) associated with uropathogenic Escherichia Coli (UPEC) are common among healthy, reproductive-aged women...

Recurrent Urinary Tract Infections (R-UTIs) are common in postmenopausal women. Recurrence is defined as three or more episodes in 12 months or two or more episodes in 6 months. Post-coital R-UTIs may represent the sole or predominant pattern of recurrence. Pathophysiology of R-UTIs is complex. Multiple factors may play a role in determining the persistence of Lower Urinary Tract Symptoms – LUTS, and the recurrence of cystitis...

The study aimed to assess the effect of palmitoylethanolamide + transpolydatin combination in patients with vestibulodynia undergoing transcutaneous electrical nerve stimulation (TENS) therapy and to confirm the effectiveness of TENS also in a domiciliary protocol...

Testosterone supplementation can be considered as a treatment option for surgically postmenopausal women with a distressful low sexual desire disorder, while on oestrogen therapy with or without progestagens. The purpose of this study is to review the available clinical data on the impact of exogenous testosterone containing postmenopausal hormone therapy on breast cancer risk...