Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation
Murina F. Graziottin A. Felice R. Radici G. Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + Transpolydatin and transcutaneous electrical nerve stimulation Journal of Lower Genital Tract Disease 2013 Apr; 17 (2): 111-6
The study aimed to assess the effect of palmitoylethanolamide + transpolydatin combination in patients with vestibulodynia undergoing transcutaneous electrical nerve stimulation (TENS) therapy and to confirm the effectiveness of TENS also in a domiciliary protocol. The study is based on the premise that palmitoylethanolamide + transpolydatin combination may contribute to a down-regulation of mast cell hyperactivity, which is believed to be responsible for the proliferation and sprouting of vestibular pain fibers and the associated hyperalgesia and allodynia.
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