Pain in gynecology and neuroinflammation: the evil twin
Graziottin A. Skaper S. Fusco M. Pain in gynecology and neuroinflammation: the evil twin Proceedings of the 16th World Congress of Gynecological Endocrinology, Firenze, Italy, March 5-8, 2014, CIC Edizioni Internazionali, Roma, 2014
There is increasing evidence that gynecological disorders associated to chronic pelvic pain (CPP) and co-morbid diseases are characterized by a neuroimmune dysregulation, involving mainly mast cells' (MC) distribution/function and nerve terminal fibers. MCs dysregulation might also promote spinal and supraspinal alterations associated with CPP. Collectively, these observations propose that a pharmacological strategy targeting MCs might represent an innovative strategy for the effective management of these disorders.
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