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13/05/2013

Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy


Bitzer J. Kenemans P. Mueck A.O. FSDeducation Group (including A. Graziottin) 
Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy
Maturitas, 2008 Mar 20; 59 (3): 209-18


Testosterone supplementation can be considered as a treatment option for surgically postmenopausal women with a distressful low sexual desire disorder, while on oestrogen therapy with or without progestagens. The purpose of this study is to review the available clinical data on the impact of exogenous testosterone containing postmenopausal hormone therapy on breast cancer risk.
No prospective randomized clinical trials were found. The five studies found (two case–control studies, two cohort studies and one retrospective observational study) showed inconsistent results. All studies had severe methodological limitations. Formulations and dosages used could be considered suboptimal.
At present, there are no valid randomized or observational clinical studies that provide evidence that the addition of testosterone to conventional postmenopausal hormone therapy influences breast cancer risk.

By courtesy of Elsevier

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Keywords:
Breast Cancer - Menopause - Hormone Replacement Therapy (HRT) - Testosterone

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