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18/04/2011

The mastcell, director of chronic pelvic pain orchestra: implications for the gynaecologist


Graziottin A.
The mastcell, director of chronic pelvic pain orchestra: implications for the the gynaecologist
Plenary lecture - XIX World Congress of Gynecology and Obstetrics, organized by the International Federation of Gynecology and Obstetrics (FIGO), October 4-9, 2009, Cape Town, South Africa


Increasing evidence supports the prominent role of up-regulated mastcells (MC's) in the maintenance of chronic inflammation and in the shifting from nociceptive to neuropathic pain in the affected tissues, contributing to chronic pelvic pain (CPP).
New therapeutic lines consider reduction of agonists and/or using drugs (“antagonists”) that can down-regulated the release of pro-inflammatory, angiogenic and neurotrophic factors from the mastcells.
Gynaecologist’ may improve CPP by understanding the pathophysiology of MCs in chronic inflammation and addressing it in a multimodal therapeutic process.

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Available documents:
Full text of the lecture

Keywords:
Interstitial Cystitis - Neuropathic Pain - Nociceptive Pain - Chronic Pelvic Pain - Endometriosis - Gynaecology - Inflammation - Mastcells - Irritable Bowel Syndrome - Pain System - Vulvar Vestibulitis / Provoked Vestibulodynia

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