Alessandra Graziottin Foundation onlus - for the cure and care of pain in womenAlessandra Graziottin Foundation

Sharing knowledge - A PDF's selection

Pain in gynecology and neuroinflammation: the evil twin

Graziottin A. Skaper S. Fusco M.
Pain in gynecology and neuroinflammation: the evil twin
Proceedings of the 16th World Congress of Gynecological Endocrinology, Firenze, Italy, March 5-8, 2014, CIC Edizioni Internazionali, Roma, 2014

There is increasing evidence that gynecological disorders associated to chronic pelvic pain (CPP) and co-morbid diseases are characterized by a neuroimmune dysregulation, involving mainly mast cells' (MC) distribution/function and nerve terminal fibers...

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Inflammation and chronic pelvic pain: a biological trigger for depression in women?

Graziottin A. Skaper S. Fusco M. 
Inflammation and chronic pelvic pain: a biological trigger for depression in women?
Journal of Depression & Anxiety, 2013, 3, 1, 1000142. doi:10.4172/2167-1044.1000142

Chronic inflammation, pain and depression are a clinical triad increasingly recognized as co-morbid. Peripheral and central inflammation can alter neuronal activity, thereby contributing to the psycho-emotional and somatic symptoms of depression. Preliminary evidence suggests that mast cells direct the immune pathways mediating this triad...

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Secondary provoked vestibulodynia in sexually-active women with recurrent uncomplicated urinary tract infections

Salonia A. Clementi MC. Graziottin A., Nappi RE. Castiglione F. Ferrari M. Capitanio U. Damiano R. Montorsi F.
Secondary provoked vestibulodynia in sexually-active women with recurrent uncomplicated urinary tract infections
J Sex Med. 2013 Sep; 10 (9): 2265-73. doi: 10.1111/jsm.12242. Epub 2013 Jul 22.

Uncomplicated recurrent urinary tract infections (rUTIs) associated with uropathogenic Escherichia Coli (UPEC) are common among healthy, reproductive-aged women. Provoked vestibulodynia (PVD) is a major reason of sexual pain in premenopausal women...

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Recurrent Urinary Tract Infections (R-UTIs): a new vision in gynaecology

Grassi D. Graziottin A.
Recurrent Urinary Tract Infections (R-UTIs): a new vision in gynaecology
Abstracts of the 13th World Congress on the Menopause, Roma, Italy, June 8-11, 2011, Climacteric, vol. 14, suppl. 1, June 2011

Recurrent Urinary Tract Infections (R-UTIs) are common in postmenopausal women. Recurrence is defined as three or more episodes in 12 months or two or more episodes in 6 months. Post-coital R-UTIs may represent the sole or predominant pattern of recurrence. Pathophysiology of R-UTIs is complex...

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Vestibulodynia: synergy between palmitoylethanolamide + Transpolydatin and transcutaneous electrical nerve stimulation

Murina F. Graziottin A. Felice R. Radici G. Tognocchi C.
Vestibulodynia: synergy between palmitoylethanolamide + Transpolydatin and transcutaneous electrical nerve stimulation
Journal of Lower Genital Tract Disease 2013 Apr; 17 (2): 111-6

The study aimed to assess the effect of palmitoylethanolamide + transpolydatin combination in patients with vestibulodynia undergoing transcutaneous electrical nerve stimulation (TENS) therapy and to confirm the effectiveness of TENS also in a domiciliary protocol...

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Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy

Bitzer J. Kenemans P. Mueck A.O. FSDeducation Group (including A. Graziottin) 
Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy
Maturitas, 2008 Mar 20; 59 (3): 209-18

Testosterone supplementation can be considered as a treatment option for surgically postmenopausal women with a distressful low sexual desire disorder, while on oestrogen therapy with or without progestagens. The purpose of this study is to review the available clinical data on the impact of exogenous testosterone containing postmenopausal hormone therapy on breast cancer risk....

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Medical treatments for sexual problems in women

Graziottin A. Serafini A.
Medical treatments for sexual problems in women
in: Mulhall J.P .(Ed.) Incrocci L. Goldstein I. Rosen R. (Ass. Eds), Cancer and Sexual Health, Humana Press, 2011, p. 627-641

Cancer is increasingly more of a chronic than a fatal disease. More attention should be focused on restoring a satisfying QOL, which includes physical intimacy, sensuality, and sexuality. Unfortunately, sexual problems are usually neglected in female cancer survivors, with a specific denial of their biological basis, with symptoms being attributed to the negative psychological effect of cancer diagnosis and treatment per se and their negative affective consequences such as depression and anxiety...

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